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Emanuela Masini Selected Research

Pharmaceutical Preparations

12/2020Bioisosteric Development of Multitarget Nonsteroidal Anti-Inflammatory Drug-Carbonic Anhydrases Inhibitor Hybrids for the Management of Rheumatoid Arthritis.
10/2020Effects of New NSAID-CAI Hybrid Compounds in Inflammation and Lung Fibrosis.
9/2015Cyclodextrin complexation highly enhances efficacy of arylsulfonylureido benzenesulfonamide carbonic anhydrase inhibitors as a topical antiglaucoma agents.
11/2014Structural insights on carbonic anhydrase inhibitory action, isoform selectivity, and potency of sulfonamides and coumarins incorporating arylsulfonylureido groups.
11/2014Prevention of bleomycin-induced lung inflammation and fibrosis in mice by naproxen and JNJ7777120 treatment.
6/2012The role of cannabinoids in inflammatory modulation of allergic respiratory disorders, inflammatory pain and ischemic stroke.
5/2012Prevention of bleomycin-induced lung fibrosis in mice by a novel approach of parallel inhibition of cyclooxygenase and nitric-oxide donation using NCX 466, a prototype cyclooxygenase inhibitor and nitric-oxide donor.
6/2010Suppression of allergen-induced respiratory dysfunction and airway inflammation in sensitized guinea pigs by Mn(II)(Me(2)DO2A), a novel superoxide scavenger compound.
8/2009Anti-inflammatory effects of low molecular weight heparin derivative in a rat model of carrageenan-induced pleurisy.
9/2005Novel drug development opportunity for relaxin in acute myocardial infarction: evidences from a swine model.
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Emanuela Masini Research Topics

Disease

22Glaucoma
11/2021 - 09/2005
18Neoplasms (Cancer)
12/2018 - 01/2002
17Inflammation (Inflammations)
10/2020 - 03/2004
12Ischemia
01/2021 - 05/2003
11Pain (Aches)
10/2021 - 06/2004
10Reperfusion Injury
11/2013 - 07/2002
9Fibrosis (Cirrhosis)
10/2020 - 04/2009
8Asthma (Bronchial Asthma)
03/2014 - 10/2004
7Hyperalgesia
10/2021 - 06/2004
6Necrosis
01/2017 - 08/2002
5Anaphylaxis (Anaphylactic Shock)
01/2022 - 08/2002
5Neuralgia (Stump Neuralgia)
10/2021 - 12/2015
5Ocular Hypertension (Glaucoma, Suspect)
01/2021 - 06/2011
5Body Weight (Weight, Body)
01/2021 - 09/2003
5Hypersensitivity (Allergy)
02/2020 - 06/2007
5Cough
03/2014 - 10/2004
5Colorectal Neoplasms (Colorectal Cancer)
12/2008 - 03/2003
4Airway Remodeling
01/2019 - 03/2014
4Pneumonia (Pneumonitis)
01/2016 - 05/2012
4Colonic Neoplasms (Colon Cancer)
12/2008 - 04/2004
4Dyspnea (Shortness of Breath)
02/2008 - 10/2004
4Squamous Cell Carcinoma of Head and Neck
02/2006 - 07/2002
3Immune System Diseases (Immune Disorders)
01/2019 - 11/2014
3Heart Failure
11/2013 - 07/2002
3Infarction (Infarctions)
09/2012 - 05/2003
3Myocardial Infarction
01/2008 - 05/2005
3Squamous Cell Carcinoma (Epidermoid Carcinoma)
02/2006 - 01/2002
2Metabolic Diseases (Metabolic Disease)
01/2019 - 01/2018
2Genomic Instability
03/2018 - 11/2017
2Chronic Pain
01/2018 - 11/2007
2Neuroinflammatory Diseases
01/2017 - 06/2012
2Pulmonary Fibrosis (Fibrosing Alveolitis)
01/2016 - 11/2014

Drug/Important Bio-Agent (IBA)

13Histamine (Histamine Dihydrochloride)FDA Link
01/2022 - 09/2003
12Nitric Oxide (Nitrogen Monoxide)FDA Link
01/2021 - 01/2002
12EnzymesIBA
03/2018 - 07/2002
11Pharmaceutical PreparationsIBA
12/2020 - 04/2002
10Protein Isoforms (Isoforms)IBA
01/2020 - 09/2005
8Carbonic Anhydrases (Carbonic Anhydrase)IBA
12/2020 - 09/2005
8ProstaglandinsIBA
06/2012 - 04/2002
7Histamine H4 ReceptorsIBA
02/2020 - 11/2014
7SulfonamidesIBA
12/2016 - 09/2005
7RelaxinIBA
11/2013 - 03/2004
7Superoxide DismutaseIBA
06/2010 - 07/2002
7Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA
08/2009 - 01/2002
6Bleomycin (Blenoxane)FDA LinkGeneric
10/2020 - 05/2012
6dorzolamide (Trusopt)FDA LinkGeneric
01/2020 - 06/2011
6Proteins (Proteins, Gene)FDA Link
12/2018 - 07/2002
6CytokinesIBA
01/2018 - 06/2004
6CeramidesIBA
05/2014 - 02/2008
6Cyclooxygenase 2 (Cyclooxygenase-2)IBA
05/2014 - 07/2002
6Amine Oxidase (Copper-Containing)IBA
01/2013 - 09/2003
63-nitrotyrosineIBA
05/2012 - 08/2002
5LigandsIBA
11/2021 - 06/2004
5Peroxidase (Myeloperoxidase)IBA
01/2019 - 06/2006
5Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
12/2018 - 07/2002
5Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
03/2018 - 06/2004
5CollagenIBA
01/2017 - 05/2012
5AllergensIBA
03/2014 - 12/2004
5Reactive Oxygen Species (Oxygen Radicals)IBA
06/2010 - 07/2002
5Superoxides (Superoxide)IBA
06/2010 - 07/2002
5imisopasem manganeseIBA
08/2005 - 07/2002
4Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA
12/2020 - 06/2004
4Carbonic Anhydrase InhibitorsIBA
12/2020 - 09/2005
4AntioxidantsIBA
07/2013 - 06/2006
4Carbon MonoxideIBA
07/2013 - 09/2008
4OvalbuminIBA
06/2010 - 12/2004
4Prostaglandins EIBA
08/2009 - 07/2002
4Nitric Oxide Synthase (NO Synthase)IBA
06/2006 - 01/2002
3Retinaldehyde (Retinal)IBA
11/2021 - 05/2012
3Interleukin-10 (Interleukin 10)IBA
10/2021 - 11/2013
3S-(2-guanidylethyl)isothioureaIBA
10/2021 - 01/2017
3Histamine Receptors (Histamine Receptor)IBA
10/2021 - 12/2015
3carbomerIBA
02/2019 - 02/2012
31- ((5- chloro- 1H- indol- 2- yl)carbonyl)- 4- methylpiperazineIBA
01/2019 - 11/2014
3Poly(ADP-ribose) Polymerase InhibitorsIBA
03/2018 - 03/2014
3Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA
11/2014 - 04/2002
3Dinoprostone (PGE2)FDA Link
05/2014 - 08/2003
3CarrageenanIBA
04/2010 - 06/2004
3Opiate AlkaloidsIBA
09/2009 - 11/2007
3AerosolsIBA
02/2008 - 12/2004
3NitritesIBA
05/2006 - 08/2002
2Interleukin-6 (Interleukin 6)IBA
10/2021 - 05/2012
2FructoseIBA
01/2021 - 01/2018
2Glucose (Dextrose)FDA LinkGeneric
01/2021 - 01/2018
2LipidsIBA
01/2021 - 01/2018
2JNJ 10191584IBA
02/2020 - 12/2015
2Adrenergic Agents (Adrenergic Drugs)IBA
02/2020 - 01/2018
2BenzenesulfonamidesIBA
01/2020 - 09/2010
2Carbonic Anhydrase IXIBA
12/2018 - 09/2010
2Fluorouracil (Carac)FDA LinkGeneric
03/2018 - 11/2017
2Ophthalmic Solutions (Eye Drops)IBA
01/2018 - 10/2014
2InterleukinsIBA
01/2017 - 11/2013
2Malondialdehyde (Propanedial)IBA
01/2016 - 05/2003
28-Hydroxy-2'-DeoxyguanosineIBA
01/2016 - 06/2006
2Thiobarbituric Acid Reactive SubstancesIBA
01/2016 - 08/2009
2Transforming Growth Factors (Transforming Growth Factor)IBA
01/2016 - 11/2014
2Naproxen (Naprosyn)FDA LinkGeneric
11/2014 - 05/2012
2Caspase 3 (Caspase-3)IBA
05/2014 - 09/2005
2Heme Oxygenase-1IBA
07/2013 - 05/2003

Therapy/Procedure

7Therapeutics
02/2019 - 05/2005